|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our findings suggest that in Klf4-null cells, decreased Bnip3 expression impairs mitophagy and is associated with increased mitochondrial ROS production after mitochondrial damage, providing a rationale for their genomic instability and supports a tumor suppressive role for KLF4 in certain tumors as previously observed.
|
31839365 |
2020 |
|
Liver carcinoma
|
0.070 |
PosttranslationalModification
|
disease |
BEFREE |
Altogether, our results highlight the involvement of HIFs overexpression and BNIP3 methylation-dependent knockdown in the development of sorafenib resistance in HCC.
|
31835431 |
2019 |
|
Anxiety
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Considering the advantages attributed to pentylenetetrazole (PTZ)-induced kindling mouse model, we used the model for the following assessments: 1. to observe changes in cognition and anxiety between wild type (WT) mice and TRPM2-KO mice with the recognition of new things trial and elevated plus-maze; 2. to determine the expression of apoptosis-associated proteins (PARP1, BNIP3, AIF, and Endo G) using Reverse transcription-polymerase chain reaction (RT-PCR) and Western blot; 3. to observe neurons pathologic damages and astrocyte activation in each group.
|
31794795 |
2020 |
|
Anxiety Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Considering the advantages attributed to pentylenetetrazole (PTZ)-induced kindling mouse model, we used the model for the following assessments: 1. to observe changes in cognition and anxiety between wild type (WT) mice and TRPM2-KO mice with the recognition of new things trial and elevated plus-maze; 2. to determine the expression of apoptosis-associated proteins (PARP1, BNIP3, AIF, and Endo G) using Reverse transcription-polymerase chain reaction (RT-PCR) and Western blot; 3. to observe neurons pathologic damages and astrocyte activation in each group.
|
31794795 |
2020 |
|
Epilepsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
The transient receptor potential melastatin type 2 channel (TRPM2) is a Ca<sup>2+</sup>-permeable cation channel that contributes to cell apoptosis; its possible signaling pathway is the PARP1/BNIP3/AIF/Endo G pathway that may be related to epilepsy.
|
31794795 |
2020 |
|
Alzheimer's Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In this study, for the first time, we present, by means of a quantitative PCR protocol with reverse transcriptase, the expression of BECN1 and CASP3 genes in the neuronal CA3 region of the hippocampus with the co-expression of the mitochondrial BNIP3 gene, which genes are associated with Alzheimer's disease, in the ischemic model of Alzheimer's disease in the rat.
|
31707369 |
2019 |
|
Brain Ischemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This indicates no involvement of the BNIP3 gene along with the CASP3 gene in the CA3 region of the hippocampus in delayed neuronal death after brain ischemia.
|
31707369 |
2019 |
|
Pediatric Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, four genes (RRAS2, NLK, bcl2/adenovirus E1B protein-interacting protein 3 [BNIP3] and phorbol-12-myristate-13-acetate-induced protein 1 [PMAIP1]) targeted by miRNAs were predicted as critical genes and might be novel diagnostic biomarkers of childhood obesity.
|
31622249 |
2019 |
|
Optic Atrophy, Hereditary, Leber
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Analysis of BNIP3 and BNIP3L/Nix expression in cybrid cell lines harboring two LHON-associated mutations.
|
31584786 |
2019 |
|
Kidney Failure, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings suggest that BNIP3-mediated mitophagy has a critical role in mitochondrial quality control and tubular cell survival during AKI.
|
31515472 |
2019 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study reveals a novel role for Bnip3 in ASM functions and establishes Bnip3 as a potential target in mitigating ASM remodeling in asthma.
|
31509440 |
2019 |
|
Carotid artery occlusion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, mitophagy and mitochondrial apoptosis were stimulated in response to the mitochondrial oxidative stress in the hippocampus of tBCCAO-treated mice, and ESC treatment regulated the expression of mitophagy-related factors, including Bnip3, Beclin1, Pink1, and parkin, the LC-3 II/I ratio, and apoptosis-related factors, including p53, Bax, and caspase 3.
|
31238056 |
2019 |
|
Acute-On-Chronic Liver Failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the relationship between Mfn2 and BNIP3-mediated pathway in ACLF is still obscure.
|
31231215 |
2019 |
|
ovarian neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our research showed the inhibitory function of miR-182-5p in OC by targeting BNIP3, thus providing an experimental basis for the treatment of OC.
|
31081079 |
2019 |
|
Malignant neoplasm of ovary
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our research showed the inhibitory function of miR-182-5p in OC by targeting BNIP3, thus providing an experimental basis for the treatment of OC.
|
31081079 |
2019 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our research showed the inhibitory function of miR-182-5p in OC by targeting BNIP3, thus providing an experimental basis for the treatment of OC.
|
31081079 |
2019 |
|
Retinal Detachment
|
0.210 |
Biomarker
|
disease |
BEFREE |
Our previous study demonstrated the protective effect on detached retina by BNIP3-mediated autophagy.
|
31072291 |
2019 |
|
Neoplasm Metastasis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
For this reason, it is noted that the targeting of the BNIP3 may be useful in preventing the rapid growth and metastasis of residual HCC after IRFA.[BMB Reports 2019; 52(4): 277-282].
|
30940322 |
2019 |
|
Liver carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
For this reason, it is noted that the targeting of the BNIP3 may be useful in preventing the rapid growth and metastasis of residual HCC after IRFA.[BMB Reports 2019; 52(4): 277-282].
|
30940322 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
BNIP3 dramatically alleviated FTO-dependent tumor growth retardation and metastasis.
|
30922314 |
2019 |
|
Breast Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
BNIP3 acts as a tumor suppressor and is negatively correlated with FTO expression in clinical breast cancer patients.
|
30922314 |
2019 |
|
Malignant neoplasm of breast
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
BNIP3 acts as a tumor suppressor and is negatively correlated with FTO expression in clinical breast cancer patients.
|
30922314 |
2019 |
|
Neoplasm Metastasis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
BNIP3 dramatically alleviated FTO-dependent tumor growth retardation and metastasis.
|
30922314 |
2019 |
|
Mammary Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3.
|
30922314 |
2019 |
|
Hyperglycemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Thus, the results of this study suggest that BDNF/TrkB/HIF-1α/BNIP3-mediated mitophagy protects BMECs from hyperglycemia.
|
30877409 |
2019 |